The strongest human evidence for longevity supplementation sits with NMN/NR (proven to raise NAD+ in blood; unclear if this translates to lifespan), GlyNAC (glycine + NAC, solid RCT data showing reversal of multiple aging hallmarks), and Taurine (declining with age in humans, though causal role unproven). Fisetin and Quercetin are promising senolytics in early-phase human trials only — not ready for confident recommendation. Resveratrol's sirtuin narrative has largely failed to replicate in humans. The honest bottom line: sleep, exercise, and diet likely outperform all of these supplements combined; the stack below is a reasonable low-risk addition for adults who understand the limitations.
19 sources 3/4 moderate Updated 2026-04-15